What is the cause of the misdiagnosis of ADHD, and how devastating are the effects of misdiagnosis?
by Nick L.

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Research Paper
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| Introduction | Why I'm interested | What is ADHD? | Possible causes | Diagnosis
Treatment | Medication | Coexisting conditions | Subjectivity | Conclusion | Works Cited |




Introduction

Imagine you are an average high school student sitting in class. As you look around the room you realize that 1 in 7 of your classmates is under the influence of a powerful drug that has properties in common with both cocaine and speed. No, it’s not the newest teenage drug craze, it’s legally

prescribed stimulants. Between 1995 and 2000 the overall use of Ritalin and other stimulant drugs for Attention Deficit/Hyperactivity Disorder (ADHD) has increased by 700%. Even the diagnosis of this disorder has become much more common. ADHD is the most common neurobehavioral disorder in children, and one of the most common public health problems in children between 6 and 12 years old (Haber 3-4). Due to their sometimes heavy side effects and addictive properties, the use of stimulant drugs to treat disorders like ADHD is very controversial, especially in young children. According to a study by the American Academy of Pediatrics, about 3-5% of children have had ADHD constantly since about 1940, however in most schools, about 15% of students take ADHD medications every day (Haber 1). This means that twice as many people who don’t have ADHD are taking medications than people who do have it. How could this be? It is my belief that the misdiagnosis of ADHD is caused by a combination of incomplete diagnoses, other afflictions being mistaken for ADHD, and the sheer subjectivity of the diagnostic criteria.
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Why I'm interested

I was diagnosed with ADHD when I was 6 years old, and have been on some form of stimulant medication for almost all of my life since then. I started taking Ritalin in first grade, and since then I’ve taken a plethora of other medications including Adderall, Adderall XR and Concerta. When I was 8, I went to a semester of group therapy sessions used to treat young children (ages 6-10) with ADHD and teach them to control their behavior on their own. In seventh grade as well as in the past few months, I’ve served as an assistant to Dr. Jeff Sosne, the pediatrician who runs the group. I watched the children learn the same lessons I once learned, as well as observed them and the way they act. I spent a lot of time talking to the children’s parents as well, in some cases talking about their children and their experience with ADHD so far. My favorite part of working with the group was talking to the parents and observing their attitudes towards their children and ADHD. Seeing how the parents interact with their children and vice versa was a very interesting learning experience for me, and I’m glad I got to talk to them firsthand. Almost all of the children in the group were on some form of stimulant medication. I’ve been interested in the diagnosis and treatment of ADD/ADHD essentially since I was old enough to understand it. I’ve always had a bit of a bias towards the argument that it is diagnosed too easily, and that most people who take them don’t actually need them, but I’ve tried my best to save my personal opinions for the conclusion. I’ve also tried very hard to keep a wide variety of sources showing different opinions on the subject.

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What is ADHD?

Attention Deficit/Hyperactivity Disorder, or ADHD, is characterized by a loss of the ability to concentrate on certain tasks, unpredictable behavior and hyperactivity (Newton, Olendorf, Jeryan and Boyden 97-98). When hyperactivity is not present, it is known as ADD (Newton, Olendorf, Jeryan and Boyden 97-98). It is also known as hyperkinetic disorder (HKD) outside of America (Newton, Olendorf, Jeryan and Boyden 97-98). Symptoms of ADHD can present themselves as early as age two or three, but most commonly shows up and is diagnosed around adolescence (Newton, Olendorf, Jeryan and Boyden 97-98). Often the hyperactivity and other more severe symptoms of ADHD will lessen with age, but the more subtle ones such as inattention to detail may well stay with the patient until adulthood and throughout the patient’s life (Newton, Olendorf, Jeryan and Boyden 97-98). A child with ADHD may be very smart, but still receive poor grades due to their inability to focus on their work (Newton, Olendorf, Jeryan and Boyden 97-98). Common symptoms of ADHD in children include being overly active, constantly moving, running, climbing, squirming and fidgeting (Newton, Olendorf, Jeryan and Boyden 97-98). It is thought to be hereditary as statistics show that children of people with ADHD are much more likely to have it (Newton, Olendorf, Jeryan and Boyden 97-98). Some believe that it is caused by an imbalance in the brain’s neurotransmitters, which are chemicals that send messages from one’s brain to the rest of one’s body (Newton, Olendorf, Jeryan and Boyden 97-98).

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Possible causes

There are many things associated with the cause of ADHD, but there is no one singular thing that causes it (NIMH). Surprisingly enough, ADHD is not thought to be able to be caused by any sort of emotional experience, but only by biological causes (NIMH). Having higher levels of lead in the body at a young age is associated with a higher risk of ADHD, as is smoking and/or drinking during pregnancy (NIMH).


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Diagnosis

To be diagnosed with ADD, six or more of the following symptoms of inattention must persist for at least six months to a degree that it is “maladaptive and inconsistent with developmental level”:

-Often fails to give close attention to details or makes careless mistakes in schoolwork, work, or other activities

-Often has difficulty sustaining attention in tasks or play activities

-Often does not seem to listen when spoken to directly

-Often does not follow through on instructions and fails to finish schoolwork, chores, or duties in the workplace

-Often has difficulty organizing tasks and activities

-Often avoids, dislikes, or is reluctant to engage in tasks that require sustained mental effort

-Often loses things necessary for tasks or activities

-Is often easily distracted by extraneous stimuli

-Is often forgetful in daily activities

-Often fidgets with hands or feet or squirms in seat

-Often leaves seat in classroom or in other situations in which remaining seated is expected

-Often runs about or climbs excessively in situations in which it is inappropriate

-Often has difficulty playing or engaging in leisure activities quietly

-Is often “on the go” or often acts as if “driven by a motor”

-Often talks excessively

-Often blurts out answers before questions have been completed

-Often has difficulty awaiting turn

-Often interrupts or intrudes on others (e.g., butts into conversations or games.)

(APA 63-65).

There is no objective laboratory test (urine, blood, x-ray, or psychological analysis) that can prove whether or not a person has ADHD (AAP 19). In addition, some symptoms of ADHD can be easily confused, even by mental health professionals, with the routine actions of children (AAP 19). To identify whether or not a child has ADHD, their behaviors and ability to function are compared to that of average children their age (AAP 19). To do this, the person doing the diagnosis usually relies on observations from adults that play a major role in the child’s life (i.e. parents, caregivers and teachers) (AAP 19).

There are, however, clear guidelines to help pediatricians come up with treatment plans for children with ADHD (AAP 45). These guidelines say that ADHD is a chronic disorder, and that it can change expression or form over time but will probably remain with the child all their life (AAP 45). Based on collaboration between the child, his parents, the pediatrician, teachers and even sometimes other professionals, they can set goals or desired outcomes on which they base decisions about treatment (AAP 45). The pediatrician (or whoever diagnosed the child) then recommends medication and/or behavioral therapy based on the goals that have been set (AAP 46). If these goals are not met in the timeframe set for them, the people who are involved in the treatment (parents, teachers and doctors) re-evaluate the diagnosis and review the treatment used and how well the child stayed on the treatment plan (AAP 46). The child is also re-evaluated for any possible coexisting conditions (AAP 46). The pediatrician is supposed to then periodically check in with parents, teachers and the child himself to review how well goals are being met and what side effects are being experienced by the child (AAP 46). Following these comprehensive guidelines will help to form the best treatment plan possible.

Five different types of people can officially diagnose a child with ADHD; Psychiatrists, Psychologists, Pediatricians, Neurologists and Clinical Social Workers (NIMH). Pediatricians and Neurologists can prescribe stimulants, Psychologists and Social Workers can provide counseling or therapy, and Psychiatrists can do both (NIMH).

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Treatment

Stimulant medication is the most common form of treatment for ADHD, and it is sometimes used in combination with behavioral therapy (AAP 67). Common drugs used for ADHD around the world include two main subtypes; long and short acting stimulants.

Shorter-acting Stimulants:

-Ritalin

-Methylin (methylphenidate)

-Focalin (d-methylphenidate)

-Dexedrine

-Dextrostat (d-amphetemine)

-Adderall (amphetamine mixture)

-Desoxyn (methamphetamine)

-Cylert (pemoline)

Longer-acting Stimulants:

-Concerta

-Metadate ER

-Ritalin SR

-Ritalin LA

-Methylin ER (methylphenidate)

-Adderall XR (amphetamine mixture)

(Breggin xiii).

The longer-acting forms are the same as the shorter ones, but they are prepared for a sustained release (Breggin xiii). The chemicals are unchanged but they get released into the bloodstream more slowly. For a long time, Ritalin was the most common drug used for ADHD, but it has recently been replaced by drugs like Adderall, Concerta and Focalin (Breggin 3).

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Medication

The American Academy of Pediatrics compares stimulant medications to a pair of glasses (67). When a stimulant is active in a child’s bloodstream, things are “put into focus” for the child (AAP 67). A child on stimulants will feel calmer, more focused, and will have an easier time staying on task in a classroom setting (AAP 67). Stimulants make symptoms of ADHD virtually disappear in some cases (AAP 67). However, as soon as the stimulant wears off, just as when glasses come off, things go out of focus just as much (AAP 67). Stimulant drugs have been available for a long time, but have only recently been prescribed to children (Breggin 4). For a long time, these drugs weren’t given to children because doctors were afraid of the repercussions the medications could have on the development of a young mind (Breggin 4). Now, it is common for a doctor to prescribe one or sometimes several powerful psychoactive substances to children at a time (Breggin 4).

According to a 2001 article in the American Academy of Pediatrics’ journal, the use of stimulant medications in preschool children between ages 2-4 tripled (Haber 3). 4-6 million children and many adults in the world are currently taking stimulant drugs for ADHD and similar problems (Breggin xiii). The United States Drug Enforcement Agency production quotas for methylphenidate (a chemical commonly used in ADHD medications) increased by more than 3,000 kilograms between 1990 and 1995 (Haber 3). Furthermore, more than 90% of that methylphenidate is produced and prescribed for children with ADHD (Haber 3). This is almost 6 times as much as it used to be, indicating a huge increase in the diagnosis of ADHD, especially in young children. At a center for child behavior in St. Louis, more than 30% of the children tested for ADHD didn’t meet the diagnostic criteria, but almost 20% of them were already using stimulant medications for it (Haber 2-3). Finally, at the 2002 annual meeting of the Pediatric Academic Societies, Dr. Marsha Rappley reported that a large quantity of stimulant medication was being prescribed to Michigan children without a recorded diagnosis of ADHD (Haber 2). The number of children taking medications for ADHD is constantly growing (Haber 2). Now, 30-50% of all visits to the offices of mental health professionals are for the diagnosis and/or treatment of ADHD (Haber 4).

Why is this a big deal? Some people, such as Peter R. Breggin, M.D. (Founder, Center for Study of Psychiatry and Psychology,) believe that stimulant medications can cause a gross deterioration in behavior (5). It is thought that when stimulants are given to chronically angry or violent children, they will only make their behavioral and emotional problems worse (Breggin 3). This may be a result of the fact that stimulants have many severe psychiatric side effects such as agitation, aggression, psychosis, mania, depression, and obsessive-compulsive disorder (Breggin xv).

All commonly prescribed stimulants for ADHD are either amphetamines or amphetamine-like (Breggin xv). All of them are highly addictive and subject to abuse (Breggin xv). All have properties similar to cocaine (Breggin xv). They can cause withdrawal symptoms, as well as many physical problems, such as cardiovascular dysfunction, growth suppression and tics (Breggin xv). A study conducted on animals shows that the brain does not always fully recover from the stopping of routine clinical doses of stimulant drugs (Breggin xv). As shown in both human and animal research, stimulant drugs can cause brain damage and dysfunctional side effects, such as reduced blood flow, reduced oxygen supply, reduced energy utilization, persistent biochemical imbalances, persistent loss of receptors for neurotransmitters, persistent sensitization (increased reactivity to stimulants,) permanent distortion of brain cell structure and function, and brain cell death and tissue shrinkage (Breggin 44).

Stimulant medications are well known for their long list of side effects:

Overview of Harmful Reactions to Stimulant Drugs: Ritalin, Dexedrine, Adderall, Concerta, and Metadate:

Brain and Mind Function

-Obsessive-compulsive behavior

-Zombie-like (robotic) behavior with loss of emotional spontaneity

-Drowsiness or reduced alertness

-Abnormal movements, tics, Tourette’s Syndrome

-Nervous habits

-Convulsions

-Headache

-Stroke

-Mania, psychosis

-Visual and tactile hallucinations

-Agitation, anxiety, nervousness

-Insomnia

-Irritability, hostility, aggression

-Depression, suicide, easy crying, social withdrawal

-Confusion, mental impairments

-Stimulant addiction and abuse

Gastrointestinal Function

-Anorexia

-Nausea, vomiting, bad taste

-Stomachache

-Cramps

-Dry mouth

-Constipation, diarrhea

-Liver dysfunction

Withdrawal and Rebound Reactions

-Insomnia

-Excessive sleep

-Evening crash

-Depression

-Rebound worsening of ADHD-like symptoms

-Overactivity and irritability

Endocrine and Metabolic Function

-Pituitary dysfunction, including growth hormone and prolactin disruption

-Weight loss

-Growth suppression

-Disturbed sexual function

Cardiovascular Function

-Hypertension

-Abnormal heartbeat

-Heart disease

-Cardiac arrest

Other Functions

-Blurred vision

-Hair loss

-Dizziness

-Hypersensitivity reaction with rash

(Breggin 33).

Harmful Stimulant Drug Reactions Commonly Misidentified as “Therapeutic” or “Beneficial” in Children:

Obsessive-Compulsive Effects

-Compulsive persistence at meaningless activities

-Increased obsessive-compulsive behavior

-Mental rigidity

-Inflexible thinking

-Overly narrow or excessive focusing

Social Withdrawal Effects

-Social withdrawal and isolation

-General dampened social behavior

-Reduced communication and socialization

-Depressed responsiveness to parents and other children

-Increased solitary play and diminished overall play

Behaviorally Suppressive Effects

-Compliant, instructured environments; socially inhibited, passive and submissive

-Somber, subdued, apathetic, lethargic, “dopey,” dazed, and tired

-Bland, emotionally flat, humorless, not smiling, depressed, and sad with frequent crying

-Lacking in initiative, spontaneity, curiosity, surprise, or pleasure

(Breggin 24).

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Coexisting conditions

Coexisting conditions are one of the problems that many people run into when trying to diagnose ADHD. About 50-60% of children with ADHD have at least one coexisting condition, and around 10% have 3 or more of them (AAP 199). The most common types of conditions to accompany ADHD are disruptive behavior disorders, anxiety and depressive disorders, learning disabilities and language impairments (AAP 199). Coexisting conditions often share many common symptoms with ADHD and sometimes even mimic the symptoms of ADHD (AAP 199). When the diagnosis is taking place, these symptoms can attributed to the ADHD while the other symptoms of the coexisting condition are ignored or passed over (AAP 199). This can lead to ADHD being diagnosed when the problem is truly 2 or more disorders, which is known as an incomplete diagnosis (NIMH).

In some cases, it may be that the child doesn’t have ADHD at all, but the symptoms of a disorder that usually accompanies ADHD are mistaken for ADHD because it is so much more common (AAP 205). Sometimes, especially when ADHD is diagnosed at a young age, it later turns out that the child only has the coexisting disorder, and doesn’t have ADHD at all (AAP 202). For example, Conduct Disorder is a disruptive behavior disorder that is defined as “a repetitive and persistent pattern of behavior in which the basic rights of others or major age-appropriate social rules are violated” (AAP 205). Aggressive behavior, one of the most common symptoms of Conduct Disorder, could easily be mistaken for the impulsiveness of ADHD by teachers or other adults (AAP 205). Keeping in mind that ADHD is the most common as well as most commonly known childhood behavioral disorder, it is easy to see how something like Conduct Disorder could be mistaken for ADHD. Teachers and parents are usually the people who spend the most time around children, and are usually the first one to notice symptoms. Seeing as most teachers and parents have little to no medical training, there’s a good chance none of them have even heard of Conduct Disorder. ADHD is so common that as soon as a teacher sees a sign of impulsiveness it makes perfect sense for them to think of it before anything else. This can lead to a complete misdiagnosis.

Another thing that makes coexisting conditions hard to identify is the fact that children’s behavior is constantly changing as the mind is still developing (AAP 199). Sometimes, the only thing that can be done is to wait a few years and retest the child (AAP 200).

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Subjectivity

Finally, there is the fact that the diagnostic criteria for ADHD is completely subjective. For instance, the word “often,” which appears in the diagnostic criteria well over 10 times, could be interpreted completely differently by two different people. While a teacher might say that a child forgetting to bring things to class once a month is too often, a parent might claim that once a week or more would be the limit for it to be considered ADHD. One person may think that a child twiddling his thumbs while being spoken to is too much “fidgeting” for them to listen, while another may say that as long as the child isn’t bouncing out of their chair, it’s fine.

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Conclusion

As you can see, the misdiagnosis of ADHD can be caused by many different things. A similar disorder can be mistaken for it, or it could be diagnosed as ADHD when really it is ADHD as well as something else or even several other things. This, mixed with the subjectivity of the diagnostic criteria makes it very easy to misdiagnose. As for how devastating the effects of misdiagnosis can be, there is a wide range of possibilities. Some children who don’t have ADHD but take stimulant medications may only experience some mild side effects such as decreased energy and appetite, but with a medication that can cause heart disease or cardiac arrest, there will always be a risk in taking it. Recognizing the serious nature of the diagnosis, the AAP has set diagnostic and treatment guidelines (pg. 4) to ensure that when something happens such as a child growing older to realize they don’t have ADHD at all, rather only a coexisting condition, they don’t continue to be treated for ADHD. I believe that these guidelines, if followed correctly, take away a great deal of the risk involved in taking stimulant medications. When used effectively, stimulants can be very safe and effective. In my research I have realized that the diagnosis of ADHD is a very long and continuous process that takes the mutual commitment of many people. In order to keep ADHD from being misdiagnosed, it requires the full attention of several people: a pediatrician, the parent(s), at least one teacher and of course the child themselves. If these people can all strictly adhere to the comprehensive and continuous guidelines of ADHD and its diagnosis, I believe the problem of the misdiagnosis of ADHD would be a smaller one.

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Works Cited
American Academy of Pediatrics. ADHD: A Complete and Authoritative Guide. 2004.

American Psychiatric Association. DSM-IV. Washington, DC: American Psychiatric Association, 1994.

Breggin, Peter Roger. The Ritalin Fact Book: What your doctor won’t tell you about ADHD and stimulant drugs. Oxford: Perseus, 2002.

Haber, Julian Stuart. ADHD: The great misdiagnosis. Lanham: Taylor Trade Pub., 2003.

Newton, David, Donna Olendorf, Christine Jeryan and Karen Boyden.  “Attention Deficit/Hyperactivity Disorder.” Sick! Diseases and Disorders, Injuries and Infections. 1st ed. 2000.

"NIMH: Attention Deficit/Hyperactivity Disorder". National Institute of Mental Health. February 28, 2006 .
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